Funding and
institutional review-board approval should
depend less on consent forms and more on ethics
training and strategy.
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Merriam Webster reports
that in 2005, “integrity” received more hits
than any other word in their online dictionary.
It’s not clear how many more hits scientific
integrity can take: An MIT researcher is fired
for fabricating a dozen papers. A pharmaceutical
company omits data from key publications about
side effects. A South Korean stem cell
researcher admits to a stunned nation that,
“blinded by work and a drive for achievement,”
he submitted a “fake it before you make it”
article to Science. It appears that research
misconduct has taken its place among the
epidemics that scientists need to worry
about.
An aphorism attributed to
Mark Twain holds that there are three kinds of
lies: lies, damn lies, and statistics. At first
the public points to a bad apple who paints mice
or switches out slides, and fumes if the
researcher conspires to hide it. But it takes a
village to do big science: authors,
collaborators, students, sponsors, regulators;
different languages, different countries,
disparate goals. A lone scientist can offer mea
culpa, but fraud on the scale of South Korea’s
almost always involves collusion and conspiracy,
hidden in the complexity of the research. It is
a nightmare for scientific journals, but more
than anything it terrifies the public.
Science depends on public
support. Too often, Hollywood sends the message
to a fickle public that
scientists-cum-fundraisers cannot be trusted to
make what Malcolm Gladwell calls “blink”
judgments about recruitment of egg donors, or to
review thousands of pages of data. In the wake
of the Hwang scandal in Korea, stem cell
researchers who had been worshipped as heroes
scraping for support become “rogues blinded by
ambition.” Those waging jihad against stem cell
research talk about tangled webs, and they ask
how far it is from an exaggeration of the
results to an exaggeration of the benefits of
embryonic cell research.
The solution to what the
public – incorrectly – perceives as an epidemic
of scientific misconduct is not obvious. Public
relations is not the answer. Scientists who have
spoken publicly about the Hwang matter have only
made things worse. There are dozens of
commissions on research ethics and programs to
provide certification in it. There are
conferences, journals, and agencies. Companies
post ethics codes in hallways. Government
pressure for compliance depends on funding, and
in the United States, there’s scant funding for
stem cell research.
The great hope lies in
teaching new generations of scientists, yet
there’s no evidence that it has an effect on the
rate of misconduct. Scare tactics about the fate
of Woo-suk Hwang will not transform those who
enter graduate school ready to fabricate
results, particularly when students report that
their mentors could care less about the ethics
course.
Nothing will prevent Dr.
Jekyll from becoming Mr. Hyde, but mentors and
oversight can help vulnerable newbies to science
eschew bad habits. Researchers learn what is
important by watching the boss; perhaps the boss
should learn to teach the integrity course using
lessons from the lab. Funding and institutional
review-board approval should depend less on
consent forms and more on ethics training and
strategy. University compliance should emphasize
remediation for those who play with matches
rather than punishment for burning down the
house.
Ultimately we don’t have
any clue what works, but it’s a safe guess that
the institutions that innovate in research
ethics and study outcomes will be the ones that
prevent misconduct. If we’re going to throw
buckets of money at frontier science, we’d
better throw a little bit more at finding the
best ways to help new scientists do it
responsibly.
Glenn McGee is the
director of the Alden March Bioethics Institute
at Albany Medical College, where he holds the
John A. Balint Endowed Chair in Medical
Ethics.
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